On Monday, January 3, 2022, eSirius was replaced with the Cayuse Animal Management System.

All data from eSirius was migrated to the new system.

Log in to with your Cornell NetID and password at this new URL: https://cornell.esirius.cayuse.com/. Be sure to update your bookmarks.

Note: You are no longer required to use the VPN when off campus.

Training & Support

Click the Cayuse Guidance Documents and Support button above for information about training and support. You can attend office hours for 1-1 support or sign up for training sessions. 

Questions?

For help, questions, or feedback about the system, contact the Research Administration Information Services (RAIS) team at: rass@research.cornell.edu.

This page contains information on how to submit an amendment to your IACUC protocol.

General Guidance About Amendments

  • You can only submit an amendment to a current, approved protocol (not to protocols that are in pending, expired or terminated status).
  • If you have a pending amendment, you cannot submit another one other than a separate personnel amendment concurrently.
  • It is always a good idea to start in Section 0 to see if you need to change any of the "Yes/No" buttons on the species-related activities. (When No is checked those sections will NOT open for you.)
  • Once the amendment is approved, the changes requested in the amendment become part of the protocol. You cannot see the changes separately in the protocol. It is a good idea to keep a PDF version of the proposed amendment for your records if you need it.
  • Amendments are reviewed on a schedule with two deadlines every month. Please refer to the schedule and deadlines listed on the page. An exception is made for personnel-only amendments, or those that require only minor administrative changes.

List of Common Amendments

Different types of amending actions may be combined in a single amendment submission. In these instances, all sections related to each of the single actions must be completed.

 

When is this type of amendment required:

  • When a person will be working on the activities on the protocol in any capacity ( researcher, Vet, animal care staff etc.) is added to the protocol
  • When an individual already approved on your protocol, is no longer involved with the study. (Why is this important? To maintain accurate information on your protocol and to ensure that training, AUHSP requirements and contact information on each individual is up to date.)
  • 6: Personnel List: To Add or Remove Personnel
    • Delete Personnel:
      • Select the radio button to the left of the person’s name in the Personnel List and select Delete Personnel button. 
    • Add Personnel:
      • Select the Add Personnel button.
      • Search for person use Last Name (and First Name if required) and select from drop-down list.
      • Note: if person is not on the contacts list, please see the instructions on the Cayuse Personnel Info page to add the person.
    • Personnel Info Tab:
      • Add contact information and the person's role on the protocol.
    • Personnel Activities Tab:
      • Select new activities for already existing personnel on the protocol when new activities are added to the protocol.
      • Select the activities the new personnel will be involved with in the protocol.
    • Training Profile Tab:
      • Add the person's degrees, training, and experience with respect to the activities that they will be involved in.

Note: No personnel are allowed to work with animals on a protocol, unless the amendment is approved by the IACUC, and the protocol reflects the addition of the personnel.

When this type of amendment is required:

  • If the protocol is already approved with animals in pain category C
  • The PI wants to get permission to purchase more animals in either category
  • The PI wants to move some animals to pain categories C from another pain category approved on the protocol.

Required Cayuse sections:

  • 1: Scientific Design (usually 200 words or less): Modify the scientific design to reflect the new numbers, and/or incorporate any new design that is proposed. Provide an overview as to why the increase in animal numbers is necessary. Discuss how it affects any changes to previously described treatment and control groups, drug treatments, husbandry methods, housing conditions, etc. Modify the total number of animals requested for all years of the protocol section 5.17.
  • 5.17: Animal Numbers: Pain Categories and Numbers Justification: Update the total number of animals requested.
  • USDA Categories: Change the numbers in each category as appropriate, to correspond with the modified scientific design.
  • Justification for Number of Animals: Add specific justification for additional numbers of animals, or modify the existing justification(s) to reflect the numbers needed for the modified scientific design.
    • When possible, provide statistical power calculations to justify animal numbers. You must justify the number of groups in repeated studies in addition to justifying the number of animals per group. Examples not requiring power calculations include: pilot studies, tissue harvesting, breeding colony maintenance, etc. See Justification for numbers for examples and detailed guidance.

When this type of amendment is required:

  • If the protocol is already approved with animals in pain category D or E
  • The PI wants to get permission to purchase more animals in either category
  • The PI wants to move some animals to pain categories D or E from another pain category approved on the protocol.

Required Cayuse sections:

  • 1: Scientific Design (usually 300 words or less): Modify the scientific design to reflect the new numbers, and/or incorporate any new design that is proposed. Provide an overview as to why the increase in animal numbers is necessary. Discuss how it affects any changes to previously described treatment and control groups, drug treatments, husbandry methods, housing conditions, etc.
  • 5.17: Animal Numbers: Pain Categories and Numbers Justification: Update the total number of animals requested.
  • USDA Categories: Change the numbers in each category as appropriate, to correspond with the modified scientific design.
  • Justification for Number of Animals: Add specific justification for additional numbers of animals or modify the existing justification(s) to reflect the numbers needed for the modified scientific design.  When possible, provide statistical power calculations to justify animal numbers. You must justify the number of groups in repeated studies in addition to justifying the number of animals per group. Examples not requiring power calculations include: pilot studies, tissue harvest constraints, breeding colony purposes, etc. See Justification for numbers requested for details and examples.
    • When possible, provide statistical power calculations to justify animal numbers. You must justify the number of groups in repeated studies in addition to justifying the number of animals per group. Examples not requiring power calculations include: pilot studies, tissue harvesting, breeding colony maintenance, etc. See Justification for numbers for examples and detailed guidance
  • 5.18: Procedures that cause discomfort, distress, or pain: Complete or modify this section to appropriately address pain and/or distress of the animals added (or moved) to category D or E. Contact a CARE Veterinarian if you need assistance. Be certain to address how you will determine the need for humane intervention based on quantitative measures as much as possible. (ACUP 402 - Humane intervention).
  • Search for Alternatives: Adjust your explanations for the 3-R's as appropriate
  • Modify the total number of animals requested for all years of the protocol in section 5.17.

When this type of amendment is required:

  • If the protocol is NOT Approved for pain categories D or E and
    • the PI wants to get permission to purchase animals in either category, OR
    • The PI wants to move some animals to pain categories D or E from another pain category approved on the protocol.

In most instances adding pain category D and/or E will also mean changing or adding procedures in the protocol. See also Add non surgical procedures, Add surgical procedures, Add/modify Drugs as appropriate.

Required Cayuse sections:

  • 1: Scientific Design (usually 500 words or less): Modify the scientific design to reflect the new numbers, and/or incorporate any new design that is proposed. Specifically describe why it is necessary to introduce pain and distress to your protocol, and its importance in achieving the goals of your research plan. Discuss any changes to previously described treatment and control groups, drug treatments, husbandry methods, housing conditions, etc.
  • 5.17: Animal Numbers: Pain Categories and Numbers Justification: Update the total number of animals requested.
  • USDA Categories: Change the numbers in each category as appropriate, to correspond with the modified scientific design.
  • Justification for Number of Animals: Add specific justification for additional numbers of animals or modify the existing justification(s) to reflect the numbers needed for the modified scientific design.  When possible, provide statistical power calculations to justify animal numbers. You must justify the number of groups in repeated studies in addition to justifying the number of animals per group. Examples not requiring power calculations include: pilot studies, tissue harvest constraints, breeding colony purposes, etc. See Justification for numbers requested for details and examples.
    • When possible, provide statistical power calculations to justify animal numbers. You must justify the number of groups in repeated studies in addition to justifying the number of animals per group. Examples not requiring power calculations include: pilot studies, tissue harvesting, breeding colony maintenance, etc. See Justification for numbers for examples and detailed guidance.
  • 5.18: Procedures that cause discomfort, distress, or pain: Complete this section to address expected pain and/or distress experienced by animals added in category D or E, monitoring plans, and specific procedures designed to minimize pain and distress. Contact a CARE Veterinarian if you need assistance. Be certain to describe how you will determine humane intervention points based on quantitative data. (ACUP 402 - Humane intervention)
  • 5.18: Alternatives Search: Conduct and report on a literature and any other searches for alternatives. All changes adding pain categories D or E for the first time must include a new search for alternatives. Describe these searches, and specifically discuss how you have addressed each of the 3-R's. See Alternatives for examples.

Additional sections that may need to be completed:

  • 5.3 List of Animal Housing and Procedure (Use) Locations
  • 5.9 Restraint Types
  • 5.11 Non-Surgical Procedures
  • 5.12 Surgical Procedures
  • 5.15 Substances Administered to Animals

When this type of amendment is required:

  • The PI is requesting permission to make a change to an already approved non-surgical procedure
  • The PI is requesting permission to add a new non-surgical procedure

Note: If the added or changed non-surgical procedure causes more than momentary pain or distress, this will require changing the numbers of animals in pain category D and/or E. See also Adding/moving animals to categories D & E or Add pain category D or E.

 

Required Cayuse sections:

  • 0: Protocol Introduction: If you do not already have an approved non-surgical procedure you will need to change the status of the Yes/No answer to the non-surgical procedures question in the Species Table first!
  • 1: Scientific Design (usually 200 words or less): Modify the scientific design to reflect the new and/or changed non-surgical procedures. Discuss changes to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.8: Sequential List or Timeline of Procedures: Add to or modify this section to reflect the changes in non-surgical procedures made to the scientific design. Describe how this additional procedure will be incorporated into the timeline of your existing procedures.
  • 5.11: Non-Surgical Procedures: Check the box that applies to the procedure(s) that you are adding.  Provide detailed information on each new non-surgical procedure, and/or modify existing detailed information to reflect the changes in non-surgical procedures made to the scientific design.
  • 6: Personnel List: Indicate who in your research team will be performing the procedures and their training

 

Additional sections that may need to be completed:

  • 5.3 List of Animal Housing and Procedure (Use) Locations: If a new location for the new or changed non-surgical procedure(s) is being used, complete this section.
  • 5.9 Restraint Types: If the new and/or changed non-surgical procedure involves the use of a restraint, this section will need to be completed or modified as appropriate. If you do not already have an approved restraint you must first change the Yes/No answer in Section 0 adding restraints!
  • 5.15 Substances Administered to Animals
  • 5.18 Procedures that cause discomfort, distress, or pain

When this type of amendment is required:

  • The PI is requesting permission to make a change to an already approved surgical procedure
  • The PI is requesting permission to add a new surgical procedure

Adding or changing a surgical procedure may require Add/move animals to categories D & E, Add pain category D or E, or Add / remove Drugs.

Required Cayuse sections:

  • 0: Protocol Introduction: If you do not already have an approved surgical procedure you will need to change the status of the Yes/No answer to the surgical procedures question in the Species Table first!
  • 1: Scientific Design (usually 300 words or less): Modify the scientific design to reflect the new and/or changed surgical procedures. Discuss changes to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.8: Sequential List or Timeline of Procedures: Add to or modify this section to reflect the changes in surgical procedures made to the scientific design. Describe how this additional procedure will be incorporated into the timeline of your existing procedures.
  • 5.12: Surgical Procedures: Add the procedure or choose an existing procedure to modify.  Provide detailed information on each new surgical procedure, and/or modify existing detailed information to reflect the changes in surgical procedures made to the scientific design. If a new location for the new or changed surgical procedure(s) is being used, complete this section.
  • 6: Personnel List: Indicate who in your research team will be performing the procedures and their training.

 

Additional sections that may need to be completed:

  • 5.3 List of Animal Housing and Procedure (Use) Locations: If a new location for the new or changed surgical procedure(s) is being used, complete this section.
  • 5.15 Substances Administered to Animals

When this type of amendment is required:

  • If you are adding new drugs to be used with animals.
  • You want to change dosages or routes of administration for a drug that you were previously approved to use on your protocol.

 

Required Cayuse sections:

  • 0: Protocol Introduction: If you do not already have an approved drug you will need to change the status of the Yes/No answer to the administered substances question in the Species Table first!
  • 5.15 Substances Administered to Animals.
  • 6: Personnel List: Indicate who in your research team will be performing the procedures and their training.

 

If the drug is identified as a potential hazard to animal and/or human health, sections related to Adding/modifying hazardous agents will also need to be completed.

Additional sections that may need to be completed:

  • 1. Scientific Design (usually 200 words or less): If necessary, modify the scientific design to reflect the new and/or changed drug usage. Discuss changes, if any, to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.14 Hazardous Agents

When this type of amendment is required:

  • If you are adding new restraints to your protocol to be used with animals.
  • If a restraint that you were previously using on your protocol is no longer being used

 

Required Cayuse sections:

  • 0: Protocol Introduction: If you do not already have an approved restraint you will need to change the status of the Yes/No answer for the restraint use question in the Species Table first!
  • 5.9: Restraint Types
  • 6: Personnel List: Indicate who in your research team will be performing/administering the restraints and their training.

Additional sections that may need to be completed:

  • 1 Scientific Design (usually 200 words or less): : If necessary, modify the scientific design to reflect the new and/or changed restraint. Discuss changes, if any, to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.3 List of Animal Housing and Procedure (Use) Locations: If a new location for the new or changed restraint is being used, complete this section.
  • 5.18 Procedures that cause discomfort, distress, or pain: If the change in restraint is expected to impact the pain or distress to the animal.

When this type of amendment is required:

  • When a new hazardous agent needs to be added to the protocol
  • When additional information is made available on an existing hazardous agent that requires changes to SOPs, PPE, safety precautions etc.

Required Cayuse sections:

  • 0: Protocol Introduction: If you do not already have an approved hazardous agent you will need to change the status of the Yes/No answer for the hazardous agent use in the Species Table first!
  • 1: Scientific design (usually 200 words or less): Modify the scientific design to reflect the new and/or changes in hazardous materials. Discuss changes to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.14: Hazardous agents (as they relate to each species that you will be using): Add or remove hazardous agents as appropriate.  For each new hazardous agent complete all the sections. If there is updated information for a listed hazardous agent add or change information as appropriate. Provide enough detail so that the AUHSP (Animal Users Health & Program) group can adequate evaluate the risks.
  • 6: Personnel List: Indicate who in your research team will be using the hazardous agents and their training.

The following sections will also need to be completed if you previously had NO hazardous agents associated with your protocol:

  • 4: Use of Hazardous Agents

 

When this type of amendment is required:

  • When there are changes to the current method of euthanasia approved on your protocol
  • When a new method of euthanasia is requested

Required e-Sirius sections:

  • 0: Protocol Introduction: If you do not already have an approved euthanasia method you will need to change the status of the Yes/No answer to the euthanasia question in the Species Table first!
  • 5.16 Euthanasia Method Information
  • 6: Personnel List: Indicate who in your research team will be performing euthanasia (if this has changed) and their training

Additional sections that may need to be completed:

  • 1. Scientific Design (usually 200 words or less): If necessary, modify the scientific design to reflect the new and/or changed euthanasia approach. Discuss changes, if any, to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.15 Substances Administered to Animals  Be sure to add any new drugs being administered for euthanasia to this section.
  • 5.18 Procedures that cause discomfort, distress, or pain if the change in euthanasia method is expected to impact the pain or distress to the animal.

When this type of amendment is required:

  • Whenever you will deviate from established standards of care as specified in The Guide for this species. Most often this is because of housing (caging) or husbandry practices required by the research or teaching.

Required Cayuse sections:

  • 5.19 Exemptions from Standards of Care: Complete all sections in detail to describe the deviation(s).

Additional sections that may need to be completed:

  • 1. Scientific Design (usually 300 words or less): If necessary, modify the scientific design to reflect the new exemption from standards of care. Discuss changes, if any, to treatment and control groups, and any impact upon previously described drug treatments, husbandry procedures, housing conditions, etc.
  • 5.18 Procedures that cause discomfort, distress, or pain if the change in euthanasia method is expected to impact the pain or distress to the animal.

When this type of amendment is required:

  • Whenever you need to add, or to change a housing location. (Note: when whole facilities close/open the changes may be made administratively.)

Required Cayuse sections:

  • 5.3 List of Animal Housing and Procedure (Use) Locations
  • 5.6: Veterinary Care, Quarantine and Acclimation: specify if there are any changes to these as a result of change of housing locations.

May also need:

  • 5.4: Transportation or Movement of Animals: if there will be changes to the way in animals will be transported due to a change in housing location.

Please note: Housing locations must be approved by the IACUC before animals are housed.

When this type of amendment is required:

  • Whenever you want add or change a location to carry out a procedure on animals.

Required Cayuse sections:

  • 5.3 List of Animal Housing and Procedure (Use) Locations
  • Please note: Procedure rooms must be approved by the IACUC before work can be performed in them.

Additional sections that may need to be completed:

  • 5.9 Restraint Types: If the new procedure room is to be used for restraint.
  • 5.12 Surgical Procedures: If the new procedure room is to be used for surgery.

Note that the guidance provided for each amendment type is based on the assumption that the PI is requesting ONLY that particular change in the approved protocol. For example, if you are requesting permission to add animals to pain category C as well as use new drugs or perform new procedures, you must follow the guidance provided in (2), (4) and (7). However, if you are adding animals to pain category C and do not propose to make any other changes to your protocol, you only need to follow the guidance provided in (2).