Submit a third year renewal for existing IACUC protocol

On Monday, January 3, 2022, eSirius was replaced with the Cayuse Animal Management System.

All data from eSirius was migrated to the new system.

Log in to with your Cornell NetID and password at this new URL: Be sure to update your bookmarks.

Note: You are no longer required to use the VPN when off campus.

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Click the Cayuse Guidance Documents and Support button above for information about training and support. You can attend office hours for 1-1 support or sign up for training sessions. 


For help, questions, or feedback about the system, contact the Research Administration Information Services (RAIS) team at:

How to submit a third year renewal in Cayuse Animal Management System (formerly eSirius)

  1. Click on
  2. In the section  3rd Year Reviews Due, you will find a listing for the expiring protocol(s).
  3. To start the third year renewal, click on the Protocol number (in blue). DO NOT SELECT THE OPTION "Create a protocol from an existing protocol". This will assign a new protocol number to your 3rd year renewal application.
  4. On the next page enter a brief progress report on your protocol. Indicate if the protocol will be renewed, or will lapse/terminate upon expiration. Select Save changes, then select Start 3rd Year Review.
  5. To terminate the protocol: indicate the disposition of the animals then select Save changes then select Submit to IACUC. The protocol will continue to appear on your home page in Approved Protocols until the IACUC Administrator approves the termination. Once the protocol is terminated, you will receive a notification from Cayuse.
  6. To renew the protocol: Open and review every section of the protocol.
    1. Carefully update, add or remove the information on this protocol as if you were submitting a new protocol.
    2. In sections with no changes, click into a text section then scroll down to select Save changes. 
    3. In sections with rows of data, highlight each row and select Edit Procedure.  Scroll to the bottom and select Save changes (even if no changes were made).
    4. In sections with only radio buttons, toggle the button from and to the correct selection, scroll to the bottom and select Save changes. 
    5. There must be green checks next to each item in the left menu in order to submit. 
  7. You can exit and update the protocol later. You will find the protocol in the Draft Protocols section.
  8. When you are done making your changes, select Submit to send the protocol to the IACUC office.  Once submitted, it will be in the Submitted Applications section.
  9. The IACUC will put your protocol on the agenda for the next IACUC meeting and review your protocol as a new submission.